Now available: Issue 11 of the RESILIA Tissue Insider

March 2025

Issue 11

In this issue, we introduce our new series of Feature articles, celebrating the history of prosthetic heart valve innovation. Other highlights include:

  • 5-year real-world outcomes of the INSPIRIS RESILIA valve
  • Two billion cycles: INSPIRIS RESILIA valve demonstrates 50 years of mechanical durability
  • RESILIA tissue valves: Sustained excellent safety outcomes in patients with aortic stenosis, aortic regurgitation or mixed aortic valve disease
  • Congress highlights from DGTHG and STS
Read more     

Last year, cardiac surgery lost a true pioneer – Dr Albert Starr. In this issue, we reflect on his legacy and, in particular, his special partnership with Miles ‘Lowell’ Edwards that resulted in the first successful artificial heart valve to be implanted in humans.

Many breakthroughs in cardiac surgery have followed, including the development of RESILIA tissue valves. Now with over 13 years of clinical experience, RESILIA tissue has taken performance and durability to new heights, transforming the tissue valve landscape. In this issue, we share the latest data supporting the performance of RESILIA tissue, including 5-year real-world data for the INSPIRIS RESILIA valve, demonstrating that more than 65 years on, we are still committed to world-leading innovation.

Discover more on RESILIA tissue through the current and past issues below.

Past issues

April 2022

Issue 1
  • Haemodynamic change over 5 years following RESILIA tissue valve AVR
  • Congress deep dive – Professor Ruggero De Paulis on INDURE registry
  • Positive 3-year results for INSIRIS RESILIA valve
  • Influence of tissue technology on pannus formation on bioprosthetic heart valves
  • Prof. Soo’s review of INSPIRIS RESILA valve

September 2022

Issue 2
  • SAVR outcomes in patients under 60 years old
  • Congress deep dive – Dr. Joseph Bavaria on a sub-analysis of 5-year COMMENCE data
  • Five-year outcomes following bicuspid aortic valve replacement with RESILIA tissue
  • INSPIRIS RESILIA valve: A 1 billion cycle in vitro study
  • Valves in practice: Prof. Hendrik Treede

November 2022

Issue 3
  • INSPIRIS RESILIA valve milestones
  • EACTS scientific sessions
    • INDURE registry update
    • Haemodynamics of Magna Ease and INSPIRIS RESILIA valves
    • Mid-term echocardiograph results for INSPIRIS RESILIA
    • Comparison of INSPIRIS RESILIA valve with a conventional stented and rapid-deployment valve
  • EACTS lunch symposia
    • INSPIRIS RESILIA valve in bicuspid aortic valve patients
    • Aortic regurgitation in INDURE
  • Aortic valve in practice: Interview with Professor Olaf Wendler, the first physician to implant an INSPIRIS RESILA valve

April 2023

Issue 4
  • Congress highlights: Professor D’Onofrio on 5-year clinical and haemodynamic outcomes
  • Three-year outcomes for the INSPIRIS RESILIA in younger patients
  • Haemodynamic performance of INSPIRIS RESILIA in Japanese patients
  • Predicted long-term cost savings associated with RESILIA tissue valves
  • How close are we to achieving a calcification-resistant bioprosthesis?
  • Experience with RESILIA valve: Interview with Professor Vlad Gariboldi

July 2023

Issue 5
  • Congress highlights: Dr Beaver presents the COMMENCE trial 7-year data shared at the AATS Meeting in May
  • Dr Joseph Bavaria and Prof. Michael Borger share their perspectives on the COMMENCE 7-year data
  • Durability of RESILIA tissue valves at 5 years compared with contemporary tissue valves
  • Mid-term performance of the INSPIRIS RESILIA valve in Japanese patients
  • Mid-term efficacy of the INSPIRIS RESILIA valve in patients under 70 years of age

November 2023

Issue 6
  • RESILIA tissue in the mitral position: learn about the features of the MITRIS RESILIA valve and the mid-term outcomes from the COMMENCE mitral clinical trial
  • INSPIRIS RESILIA valve performance in the real world, including the longest follow‑up to date
  • Cost effectiveness data associated with INSPIRIS RESILIA valve versus mechanical valves

March 2024

Issue 7
  • Read about first experiences with the MITRIS RESILIA valve, including learnings from double valve replacements
  • Seven-year data from the COMMENCE aortic trial, including a bicuspid aortic valve sub-analysis
  • INSPIRIS RESILIA valve performance in the real world

July 2024

Issue 8
  • Data on the INSPIRIS RESILIA valve in younger patients presented at the SFCTCV meeting in France
  • Analysis of the INSPIRIS RESILIA valve in bicuspid versus tricuspid morphology from the IMPACT and INDURE registries
  • Subgroup analysis of the 5-year outcomes for patients with mixed aortic valve disease from the COMMENCE aortic trial

October 2024

Issue 9
  • From the beginning: The first implantation of the INSPIRIS RESILIA valve
  • The importance of innovation in cardiac surgery
  • Looking to the future with RESILIA tissue: Lifetime management and valve-in-valve technology
  • Implanting the INSPIRIS RESILIA valve: A spotlight on patients

Click here to download the INSPIRIS RESILIA aortic valve Data Compendium

This healthcare professional focused booklet explores the latest clinical studies and publications involving the INSPIRIS RESILIA valve and RESILIA tissue through the review of 24 publications and abstracts.

Each reference has been summarized visually over 1 or 2 slides, for you to save time.

Videos Selected by Edwards

*Clinical data on valves with RESILIA tissue up to 7-year follow-up have been published, with additional follow-up to 10-years in progress.

†RESILIA tissue tested against tissue from commercially-available bovine pericardial valves from Edwards in a juvenile sheep model. Flameng, et al. J Thorac Cardiovasc Surg 2015;149:340–5

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Medical device for professional use. For a listing of indications, contraindications, precautions, warnings, and potential adverse events, please refer to the Instructions for Use (consult eifu.edwards.com where applicable).